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GEM 21S® Growth Factor Enhanced Matrix

GEM 21S® is a synthetic bone graft composed of purified, sterile recombinant (bioengineered) platelet-derived growth factor (rhPDGF) and β-TCP. PDGF is naturally found in the body (present in the platelets in your blood) and is often referred to as nature’s wound healing protein. GEM 21S® increases the amount of PDGF at the grafted site to aid in faster, more bone and better healing.1

 

Key Benefits:

  • Completely synthetic growth factor-enhanced matrix with rhPDGF-BB and β-TCP.
  • Promotes regeneration of bone, periodontal tissues, and peri-implant structures.
  • Facilitates angiogenesis and osteogenesis, mimicking the body's natural healing processes.

References:

  1. GEM 21S® Instructions for Use.
  2. Wang HL, et al.: J Periodontol. 1994 May; 65 (5): 429-36.
  3. Graves DT. Ann Periodontol. 1997; 2: 259-267.
  4. Piche JE, et al.: Bone. 1989; 10(2): 131-189.
  5. Based on in-vitro and in-vivo data.
  6. Lynch SE, Introduction: Tissue Engineering, Applications in Maxillofacial Surgery and Periodontics. Lynch SE, Genco RJ and Marx RE Eds. Quintessence Publishing Co. 1999.
  7. Nevins M. et al.: J Periodontol. 2003 Sep; 74(9):1282-92.
  8. McGuire M, et al.: Int J Periodontics Restorative Dent. 2009; 29:7-21.
Optimising Soft Tissue & Bone Healing for Teeth & Implants by Dr Michael McGuire & Dr. Todd Scheyer

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The Science
Consistency
rhPDGF-BB is released from the β-TCP matrix into the surrounding environment. rhPDGF-BB then binds to specific cell surface receptors on target cells, initiating a cascade of intracellular signaling pathways.
Cellular Attraction
rhPDGF-BB-induced intracellular events lead to directed cell migration (chemotaxis) and cell proliferation (mitogenesis) of osteoblasts, periodontal ligament fibroblasts and cementoblasts.*
Cellular Proliferation
Proliferation of osteoblasts, periodontal ligament fibroblasts and cementoblasts leads to increased matrix synthesis, resulting in formation of new alveolar bone, periodontal ligament and cementum.* Angiogenesis (blood vessel formation) continues.
Clinical Outcomes
Clinical data suggests that over time (approximately 6 months), maturation of supporting alveolar bone, cementum, and periodontal ligament occurs. The end result is enhanced bone and periodontal regeneration and retention of the natural tooth.
How Dr. Sam Lynch Revolutionised Oral Surgery With GEM 21S® & Growth Factors
Downloads
GEM 21S® Brochure
GEM 21S® Patient Implant Card
GEM 21S® Patient Information Leaflet
GEM 21S® IFU
Lucky Regeneration Draw T&C

Pair your GEM 21S® with Geistlich Bio-Oss® Collagen