Fundamentally, the use of small particles is recommended for small defects (up to 2 dental alveoli) and for augmenting autogenous grafts, and the large particles for large defects (> 2 dental alveoli, sinus lifts). However, preferences can vary from dentist to dentist.
A membrane should be used as a barrier against ingrowth of soft tissue1. Native collagen membranes such as Geistlich Bio-Gide also support wound healing and increase therapeutic safety in the event of a postoperative wound dehiscence2,3. Physicians should read the package insert prior to use.
References:
Gielkens PF, et al.: Clin Oral Implants Res 2008; 19: 516-21.
Tal H, et al.: Clin Oral Implants Res 2008; 19: 295-302.
Becker J, et al.: Clin Oral Implants Res 2009; 20(7): 742-49.
Depending on the size of the defect between 1.5 to 4 cc of Geistlich Bio-Oss® granules are needed, or 3cc in average. This is equivalent to two 1.5cc Geistlich Bio-Oss Pen® with large granules or three 1cc Geistlich Bio-Oss Pen® with small granules.
No. Geistlich Bio-Oss® Collagen is a mixture of 90% Geistlich Bio-Oss® spongiosa granules and 10% highly purified porcine collagen in a block form. Geistlich Bio-Oss® is a natural bone mineral of bovine origin. The collagen facilitates adaptation of the Geistlich Bio-Oss® to the defect site.
The collagen in Geistlich Bio-Oss® Collagen does not function as a membrane. When the socket is not intact, it is recommended to use a membrane to receive optimal results1.
References:
Perelmann-Karmon, et al.: Int J Periodontics Restorative Dent 2012; 32(4): 459-65.
Since Geistlich Bio-Oss® Collagen contains collagen, allergic reactions and inflammatory tissue reactions cannot be ruled out. These are, however, extremely rare.
Geistlich Combi-Kit Collagen is recommended for the reconstruction of the alveolar ridge, extraction socket management and augmentation of bone dehiscences.
Geistlich Combi-Kit Collagen is packed in a double blister. After the outer blister has been opened sterility can no longer be guaranteed. The product Geistlich Combi-Kit Collagen is registered for one time use only. It is not recommended to use the products separately.
Since Geistlich Bio-Oss® Collagen and Geistlich Bio-Gide® are made of collagen, allergic reactions and inflammatory tissue reactions cannot be ruled out. These are, however, extremely rare.
Geistlich Bio-Gide® is a membrane with a unique bilayer structure. It combines optimal bone formation with complication –free wound healing and predictable outcomes. An exceptional number of scientific publications and proven long-term success underline the unparalleled performance of Geistlich Bio-Gide®.
Perio-System Combi-Pack is packed in a double blister. After the outer blister has been opened, product sterility can no longer be guaranteed. The product Perio-System Combi-Pack is registered for single use only.
The collagen in Geistlich Bio-Oss® Collagen does not function as a membrane. In guided bone regeneration (GBR) procedures a membrane is indicated to obtain optimal results.1
References:
Perelman-Karmon M, et al.: Int J Periodontics Restorative Dent 2013, 32(4): 459-65.
Since Geistlich Bio-Gide® Perio and Geistlich Bio-Oss® Collagen are made of collagen, allergic reactions and inflammatory tissue reactions cannot be ruled out. These are, however, extremely rare.
Alveolar bone best regenerates with a membrane designed for Guided bone regeneration. The use of a membrane leads to more and better bone compared to procedures that do not include a membrane.1
References:
Schwarz F, et al.: Clin Oral Impl Res 2008; 19(4): 402-15.
Expert oral surgeons have estimated that a membrane used in Guided Bone Regeneration should maintain its barrier function until the provisional matrix and woven bone are present. As a consequence, barrier duration is considered to be necessary for 4 to 6 weeks, in most cases. Geistlich Bio-Gide® has proven to support bone regeneration on an equivalent level as membranes with a longer barrier function, with the additional benefit of complication-free wound healing.1-4
References:
Tal H, et al. Clin Oral Impl Res 2008; 19: 295-302.
Becker J, et al. Clin Oral Impl Res 2009; 20(7): 742-49.
Schwarz F, et al. Clin Oral Impl Res 2008; 19(4): 402-15.
Nahles S, et al. Clin Oral Implants Res. 2013 Jul;24(7):812-9.
Geistlich Bio-Gide® is a membrane with a unique bilayer structure. It combines optimal bone formation with complication-free wound healing and predictable outcomes. The native collagen of Geistlich Bio-Gide® leads to significantly less dehiscence compared to artificially cross-linked membranes.4 An exceptional number of scientific publications and proven long-term success underline the unparalleled performance of Geistlich Bio-Gide®.
References:
Tal H, et al.: Clin Oral Impl Res 2008; 19: 295-302.
Inflammation is a possible complication, which may occur with any surgery. However, biocompatibility of Geistlich Bio-Gide® has been verified by testing.
Since Geistlich Bio-Gide® is made of collagen, allergic reactions and inflammatory tissue reactions cannot be ruled out. These are, however, extremely rare.
The compact layer of Geistlich Bio-Gide® exhibits higher cell occlusiveness than the rough, porous layer. If the membrane is applied side-inverted, integration of the bone cells may take place rather more slowly. However, it is not necessary to remove the membrane.
No, autoclaving or hot-air sterilization irreversibly destroys the collagen structure. The physical properties of the membrane are changed and the consistency of the product becomes like parchment paper. The membrane may not be used. In this case, Geistlich as the manufacturer, cannot accept product liability because the product is not approved for re-sterilization.
Since Geistlich Bio-Gide® adheres very well to the defect, it is normally not necessary to utilize fixation screws or pins. However, fixation is possible.
Geistlich Bio-Gide® can heal submerged or open1 depending on the surgeons preference. The advantages of the secondary intention healing of Geistlich Bio-Gide® are the flapless surgery and the preservation of the mucogingival line.
References:
Cardaropoli D, et al.: Int J Periodontics Restorative Dent 2012, 32(4): 421-30.
Geistlich Bio-Gide® Compressed has a smoother surface, a firmer feel and is easier to cut compared to Geistlich Bio-Gide®. Therefore, it offers an alternative handling for those dentists who prefer a firmer membrane. Geistlich Bio-Gide® Compressed is available in the sizes 13 x 25 mm and 20 x 30 mm. Availability may vary from country to country.
Both Geistlich Bio-Gide® Compressed and GeistlichBio-Gide® are intended to be used as barrier membranes in theregeneration of bone defects, for example in the context of Guided Bone Regeneration, for delayed or immediate augmentation around implants, reconstruction of the alveolar ridge, filling bone defects in the maxillofacial area and cleft closure surgeries. For further details, please consult the Geistlich Bio-Gide® and Geistlich Bio-Gide® Compressed IFU.
Penetration of the membrane by blood and exudate during the surgery allows excellent adhesion of the membrane to the defect. Fixation of the membrane with sutures or pins is possible due to its high tensile strength. Fixation may be indicated to avoid membrane displacement due to shear loading or mobilization.
Clinical performance of Geistlich Bio-Gide® Compressed is regarded the same as Geistlich Bio-Gide®. Various studies have shown that membranes of the Geistlich Bio-Gide® product family support excellent wound healing1-3 and predictable bone regeneration4.
Referenzen:
Tal H, et al.: Clin. Oral Implants Res 2008; 19: 295-302.
Zitzmann NU, et al.: Int J Oral Maxillofac Implants 1997; 12: 844-52.
Becker J, et al.: Clin. Oral Implants Res 2009; 20(7): 742-93.
The dense layer of Geistlich Bio-Gide® Compressed is more cell-occlusive than the porous layer. Therefore, we advise to place the membrane as described in the IFUs. However, it is not necessary to remove the membrane.
La capa compacta de Geistlich Bio-Gide® Perio es menos permeable a las células que la capa rugosa y porosa. Si la membrana se aplica con los lados invertidos, la integración de las células óseas puede producirse con bastante más lentitud. Sin embargo, no es necesario retirar la membrana.
The surface of Geistlich Bio-Gide® Perio has been made firmer when dry to facilitate periodontal applications. Second, the outer blister pack of Geistlich Bio-Gide® Perio includes four sterile water repellent templates. These can be placed repeatedly in the region of the defect to allow customization of the template before cutting the membrane to the precise shape.
Inflammation is a possible complication, which may occur with any surgery. However, biocompatibility of Geistlich Bio-Gide® Perio has been verified by testing.
Since Geistlich Bio-Gide® Perio is made of collagen, allergic reactions and inflammatory tissue reactions cannot be ruled out. These are, however, extremely rare.
No, autoclaving or hot-air sterilization irreversibly destroys the collagen structure. The physical properties of the membrane are changed and the consistency of the product becomes like parchment paper. The membrane may not be used. In this case, Geistlich as the manufacturer, cannot accept product liability because the product is not approved for re-sterilization.
Since Geistlich Bio-Gide® Perio adheres very well to the defect, it is normally not necessary to utilize fixation screws or pins. However, fixation is possible.
In general, Geistlich Bio-Gide® Shape is based on the Geistlich Bio-Gide® Perio technology to facilitate application comfort. For easier handling, the membrane is pre-cut to a shape that fits for extraction sockets. This also reduces your preparation time.
Place the membrane without pre-wetting within the extraction socket. The long strap of the Geistlich Bio-Gide® Shape should be placed to cover the bony defect of the socket, if present. Thereby the dense surface should face towards the soft tissue, and the rough side should face the defect.
To close the extraction socket, both lateral wings of the Geistlich Bio-Gide® Shape membrane should be tucked underneath the mucosa, located mesially and distally of the socket. The upper wing should be tucked lingually / pallatinally in-between the soft tissue and bone wall.
The membrane should be placed inside the alveolus or outside (between the bone and the soft-tissue). From the convenience point of view, it might be easier to place Geistlich Bio-Gide® Shape inside the alveolus.
The long strap of the Geistlich Bio-Gide® Shape should be placed to cover the bony defect of the socket, if present. Thereby the dense surface should face towards the soft tissue, and the rough side should face the defect.
Geistlich Bio-Gide® Shape and Geistlich Bio-Oss® Collagen can be used in combination for the treatment of extraction sockets with non-intact buccal bone walls.
The use of Geistlich Mucograft® Seal and Geistlich Bio-Oss® Collagen is recommended in extraction sockets with intact buccal bone walls.1
Reference:
Geistlich Mucograft Seal Advisory Board Meeting Report, 2013. Data on file, Geistlich Pharma AG, Wolhusen, Switzerland.
The device will gain approx. 25% in volume once wet. This increase in volume has to be taken into account when deciding upon final dimensions. A generous flap design is the key to full submersion of the matrix.
Geistlich Fibro-Gide® is a porcine, porous, resorbable and volume-stable collagen matrix specifically designed for soft-tissue regeneration. The matrix is made of reconstituted collagen undergoes smart chemically cross-linking to improve volume stability of the device while maintaining its excellent biocompatibility.
Geistlich Fibro-Gide® is an alternative to autologous connective tissue grafts (CTG) for soft-tissue volume augmentation around dental implants and natural teeth. Geistlich Fibro-Gide® obviously has the advantage of reducing patient morbidity since there is no additional harvest site. Furthermore, there is no risk of necrosis when using Geistlich Fibro-Gide® compared to CTG.
Geistlich Fibro-Gide® can be applied either in a dry or wet state subject to individual preference: pre-wetting can be done with blood and/or sterile saline.Geistlich Fibro-Gide® can be cut and trimmed both in a dry or wet state, using scissors and/or a scalpel. The scalpel is recommended for dry handling. Using a scalpel will help to obtain smooth edges and tapers for improved wound adaptation and precise fit of the matrix.
The device will gain approx. 25% in volume once wet. This increase in volume has to be taken into account when deciding upon final dimensions. A generous flap design is the key to full submersion of the matrix.
Use your preferred flap design. A generous preparation of the flap is key to promoting successful healing by complete coverage of Geistlich Fibro-Gide® (submerged healing). Different surgical techniques, such as tunneling and/or envelope techniques are currently being clinically tested (not all under studies).
Clinical experience has shown that tension-free wound closure is a key factor in preventing dehiscence. In open flap procedures for augmentation at the alveolar ridge a horizontal mattress suture is recommended to stabilize the matrix (5.0-6.0). In recession coverage single sutures (7.0) have been used for stabilization.
Clinical studies have shown a physiological increase in thickness when using CTG as the gold standard of 0.35 to 3.2 mm. Clinical studies have shown that treatment with Geistlich Fibro-Gide® results in an increase of 1-2 mm of thickness which is equivalent to results obtained with CTG. Geistlich Fibro-Gide® is provided with a thickness of 6 mm which gives freedom to the surgeon to trim it to the desired size and to use the collagen matrix for thickening of tissues under pontics where more volume might be required. For lateral soft-tissue augmentation, it is recommended to reduce the thickness of Geistlich Fibro-Gide® in order to achieve a tension-free, primary wound closure.
Geistlich Fibro-Gide® is ready to be applied to the defect and does not need pretreatment or conditioning before application. Geistlich Fibro-Gide® possesses excellent hydrophilic characteristics that lead to a rapid hydration of the collagen matrix (patient’s own blood and/or sterile saline). When applied dry to the defect site, the matrix will hydrate easily by soaking up patient’s own blood and/or sterile saline very fast.
Loading with minimal pressure can be done immediately after surgery, taking into account the swelling due to the intervention. Loading by applying pressure can be performed as soon as the site has healed 3-8 weeks after grafting and should not be delayed more than 3 months. This might be beneficial for conditioning the new soft-tissue and favoring its maturation based on experience from clinical studies.
It is important to adjust the size of Geistlich Fibro-Gide® to the dimensions of the defect site, taking swelling into consideration, in order to ensure tension-free wound closure. Slight over-augmentation with Geistlich Fibro-Gide®, on the contrary, might be needed (similar to Guided Bone Regeneration), but tension-free wound closure is key.
The result of the whole remodeling process of Geistlich Fibro-Gide® is the formation of new soft-tissue (connective tissue). Animal models have shown good integration of Geistlich Fibro-Gide® into the surrounding soft-tissue without formation of scar tissue.
Geistlich Mucograft® consists of porcine collagen and is specifically designed for soft-tissue regeneration. The matrix is built up of a compact structure that gives stability while allowing open healing, and a spongy structure that supports blood clot stabilisation and ingrowth of soft-tissue cells.
The collagen of Geistlich Mucograft® will be replaced by newly formed soft tissue. The matrix is rapidly vascularized and colonised by soft-tissue cells. This leads to a good integration of the matrix without any signs of foreign body reaction1,2.
References:
Rocchietta I, et al.: Int J Periodontics Restorative Dent 2012; 32(1): e34-40 (pre-clinical study)
Ghanaati S, et al.: Biomed Mater 2011; 6(1): 015010 (pre-clinical study)
For both. Geistlich Mucograft® is an alternative to free gingival graft or connective tissue graft for gaining keratinized tissue1-3. Geistlich Mucograft® is an alternative to CTG for recession coverage4-6.
References:
Sanz M, et al.: J Clin Periodontol 2009; 36(10): 868-76 (clinical study)
Lorenzo R, et al.: Clin. Oral Impl. Res 2012; 23(3): 316-24 (clinical study)
Nevins M, et al.: Int J Periodontics Restorative Dent 2011; 31(4): 367-73 (clinical study)
Geistlich Mucograft® is ready to be applied to the defect and does not need pretreatment or moisture before application. Due to its excellent hydrophilicity, the matrix will hydrate quickly after implantation in the defect by soaking rapidly the patient’s blood.
Published data show different suturing techniques with Geistlich Mucograft®: non-resorbable1,2 and resorbable3, 0-51,2 and 0-64. There is no clinical evidence showing a benefit of one type of suture over another one, when suturing Geistlich Mucograft®.
References:
Sanz M, et al.: J Clin Periodontol 2009; 36(10): 868-76 (clinical study)
The compact structure should face outward, away from underlying bone, with the spongeous structure facing the bone or soft-tissue wound bed. Neither clinical nor comparative data on inverted device performance is available for Geistlich Mucograft®.
In the majority of the individual cases treated thus far and for all the studies performed with Geistlich Mucograft®, one matrix layer was used. Presently, clinical data is not available to prove that several layers of the device outperform a single layer of Geistlich Mucograft®.
It depends on the indication: 1. Gain of keratinised tissue: Geistlich Mucograft® should be applied on a periosteal bed1,2 since blood supply is important. In open healing, the blood is supplied through the edges of the device from the surrounding tissue and from the periosteum. 2. Recession Coverage: Geistlich Mucograft® can be used partially or completely over bone.3-5 Blood is supplied through the edges of the device from the surrounding tissue and from the flap covering completely the matrix.
References:
Sanz M, et al.: J Clin Periodontol 2009; 36(10): 868-76 (clinical study)
Lorenzo R, et al.: Clin Oral Impl Res 2012; 23(3): 316-24 (clinical study)
It depends on the indication: 1. Gain of Keratinised Tissue: Open healing is recommended when Geistlich Mucograft® is used to increase width of keratinised tissue. The innovative design of Geistlich Mucograft® allows excellent healing in open healing situations1. 2. Recession Coverage: Geistlich Mucograft® should remain completely submerged under the flap to avoid premature resorption of the collagen.2-4 Direct blood supply is important.
References:
Sanz M, et al.: J Clin Periodontol 2009; 36(10): 868-76 (clinical study)
After treatment with Geistlich Mucograft®, please follow the same postsurgical management that is usually applied with connective tissue grafts or free gingival grafts.
Geistlich Mucograft® Seal is specifically designed for soft-tissue regeneration1. The collagen of Geistlich Mucograft® is specially processed to favour immediate blood clot stabilization. This leads to early vascularization1,3, facilitates soft-tissue cell ingrowth2 and good integration of the matrix with surrounding tissues2,3. In contrast to other collagen products in the market, Geistlich Mucograft® and Geistlich Mucograft® Seal are well scientifically documented and their clinical benefits are proven.
References:
Biocompatibility according to ISO 10993-12001. Data on file Geistlich PharmaAG, Wolhusen, Switzerland.
Ghanaati S, et al.: Biomed Mater 2011; 6(1): 015010 (pre-clinical study)
Rocchietta I, et al.: Int J Periodontics Restorative Dent 2012; 32(1): e34-40 0 (pre-clinical study)
The resorption time of every biomaterial including Geistlich Mucograft® Seal depends on multiple factors: defect size, metabolism and general health of the patient, etc. On the other hand, to determine an average resorption time of Geistlich Mucograft® Seal in humans, biopsies would be needed of the healing soft tissues after tooth extraction at different time points. This procedure is obviously not ethical and thus the average resorption time cannot be measured. However, single histologies indicate that after 8 weeks Geistlich Mucograft® is completely integrated into the newly formed soft tissue.
Geistlich Mucograft® Seal needs the support of Geistlich Bio-Oss® Collagen underneath for a good ridge preservation of the soft and the hard tissues. After 8 weeks, the soft tissues are healed but the mixture of the blood clot, Geistlich Bio-Oss® Collagen and the newly forming bone is still soft. Nevertheless the implant can be drilled carefully into the socket and the remaining Geistlich Bio-Oss® Collagen will favour the volume preservation of the ridge.
Geistlich Mucograft® Seal consists of porcine collagen and is specifically designed for soft-tissue regeneration. The matrix is built up of a compact structure that gives stability while allowing open healing, and a spongy structure that supports blood clot stabilisation and ingrowth of soft-tissue cells.
The collagen of Geistlich Mucograft® will be replaced by newly formed soft tissue. The matrix is rapidly vascularized and colonised by soft-tissue cells1,2. This leads to a good integration of the matrix without any signs of foreign body reaction3,4.
References:
Rocchietta I, et al.: Int J Periodontics Restorative Dent 2012; 32(1): e34-40 0 (pre-clinical study)
Ghanaati S, et al.: Biomed Mater 2011 Feb; 6(1): 015010 0 (pre-clinical study)
Nevins M, et al.: Int J Periodontics Restorative Dent 2011; 31(4): 367-73 0 (clinical study)
Camelo M, et al.: Int J Periodontics Restorative Dent 2012; 32(2): 167-73 0 (clinical study)
Geistlich Mucograft® Seal is ready to be applied to seal the socket and does not need pretreatment or moisture before application. Due to its hydrophilicity, the matrix will hydrate quickly after implantation in the defect by soaking rapidly the patient’s blood.
The compact structure should face outward, away from underlying bone, with the spongeous structure facing the bone or soft-tissue wound bed. Geistlich Mucograft® Seal spongeous structure is striped for easier differentiation of the two sides. The striped spongeous structure should face the bone.
Geistlich Mucograft® Seal should be sutured using non-resorbable sutures, not glued1. The close adaptation of the device to tissue borders can be accomplished by single interrupted sutures, double interrupted sutures, cross sutures, or sling sutures1. The finest possible suture material comfortably used by the surgeon should be selected: for single interrupted sutures, the 6.0 or 5.0 suture size is recommended; for cross-suturing, a 5.0 suture size is appropriate1.
References:
Geistlich Mucograft Seal Advisory Board Meeting Report, 2013. Data on file Geistlich Pharma AG, Wolhusen, Switzerland.
Fundamentally, the use of small particles is recommended for small defects (up to 2 dental alveoli) and for augmenting autogenous grafts, and the large particles for large defects (> 2 dental alveoli, sinus lifts). However, preferences can vary from dentist to dentist.
A membrane should be used as a barrier against ingrowth of soft tissue1. Native collagen membranes such as Geistlich Bio-Gide® also support wound healing and increase therapeutic safety in the event of a postoperative wound dehiscence2,3. Physicians should read the package insert prior to use.
References:
Gielkens PF, et al.: Clin Oral Implants Res 2008; 19 : 516-21.
Tal H, et al.: Clin Oral Implants Res 2008; 19: 295-302.
Becker J, et al.: Clin Oral Implants Res 2009; 20(7): 742-49.
No, if Geistlich Bio-Oss® is autoclaved, moisture can collect in the particles due to the high porosity of the product, which can change the hydrophilic properties. Moreover, Geistlich Bio-Oss® is not approved for re-sterilization in dental practice. Geistlich does not recommend re-sterilization under any circumstances.
Geistlich Bio-Oss® is made from the mineral part of bovine bone. The strictly controlled manufacturing process ensures high quality and safety standards by:
Country of origin: Australia (and for some countries also New Zealand and Switzerland)
Selected and certified slaughterhouses
Pre- and post-mortem health inspection for each individual animal
Extremity bone (according to WHO Guideline on tissue infectivity classified as tissues with no detected infectivity or infectious prions)
Effective inactivation methods with 15h treatment at high temperature and cleaning with strong alkaline solutins
Both Geistlich Bio-Oss® OR Geistlich Bio-Oss® Collagen AND Geistlich Bio-Gide® are recommended for bone regeneration in the management of extraction sockets with defect bone walls. When Geistlich Bio-Oss® and Geistlich Bio-Gide® are used in combination, more new bone is obtained compared to extraction site using only a bone substitute material1.
The use of Geistlich Mucograft® Seal and Geistlich Bio-Oss® Collagen is recommended in extraction sockets with intact buccal bone wall2.
Geistlich Bio-Gide® Shape and Geistlich Bio-Oss® Collagen can be used in combination for the treatment of extraction sockets with non-intact buccal bone wall.
References:
Perelman-Karmon M, et al.: Int J Periodontics Restorative Dent 2012; 32(4): 459-65.
Geistlich Mucograft Seal Advisory Board Meeting Report, 2013. Data on file, Geistlich Pharma AG, Wolhusen, Switzerland.
Geistlich Bio-Gide® can be healed submerged or open1 depending on the surgeons preference. The advantages of the secondary intention healing of Geistlich Bio-Gide® are the flapless surgery and the preservation of the mucogingival line.
References:
Cardaropoli D, et al.: Int J Periodontics Restorative Dent 2012; 32(4) :421-30.
It is a tooth-related structure that resorbs after tooth extraction. The buccal bone wall of the socket is very thin1-3 and consists largely of the bundle bone.
References:
Huynh-Ba G, et al.: Clin Oral Implants Res 2010; 21: 37-42.
Januario AL, et al.: Clin Oral Implants Res 2011; 22(10): 1168-71.
Regardless of the therapy approach, the bundle bone resorbs following tooth loss or extraction. The bundle bone cannot be regenerated, however Geistlich Bio-Oss® or Geistlich Bio-Oss® Collagen effectively substitutes its function in supporting soft-tissue and compensating for buccal bone loss.1,2
References:
1. Araujo M, et al.: Int J Periodont Rest Dent 2008; 28:123-135. 2. Fickl S, et al.: Journal Clin Periodontol 2008; 35:356-363.
Geistlich Mucograft® Seal needs the support of Geistlich Bio-Oss® Collagen underneath for a good ridge preservation of the soft and the hard tissues. After 8 weeks, the soft tissues are healed but the mixture of the blood clot, Geistlich Bio-Oss® Collagen and the newly forming bone is still soft. Nevertheless the implant can be drilled carefully into the socket and the remaining Geistlich Bio-Oss® Collagen will favour the volume preservation of the ridge.
Yes. Geistlich Mucograft® Seal is an alternative to autogenous soft-tissue graft for soft-tissue regeneration. Geistlich Mucograft® Seal does not require pre-hydration or washing. It should be handled and applied in a dry state. Before applying Geistlich Mucograft® Seal, adjacent soft-tissue margins should be de-epithelialized. This allows epithelial cells to freely migrate from the soft-tissue borders into the matrix.
Investigators still cannot agree on the importance of the presence of keratinised tissue. Various studies have shown, however, that lack of keratinised tissue around implants is associated with
Gingival recession over a period of five years1
Soft-tissue attachment loss2
Increased plaque accumulation lingually1
Inflammation of the soft tissue2
More frequent bleeding1
References:
Schrott AR, et al.: Clin Oral implants Res 2009; 20(10): 1170-17.
Chung DMT, et al.: J Periodontol 2006; 77(8): 1410-20.
Storage at room temperature only: +15 °C to +25 °C guarantees product quality over the shelf life duration of 3 years. For a short term (maximum of 7 days), the product can be stored at +4 °C to +40 °C.
If the product has turned to gel prior to application, e.g. due to warm room temperature, it can be placed in a refrigerator at ≥ +4 °C for approx. two minutes until it becomes liquid again.
